Basic System Concept 

By combining movement waves or impulses derived from ultra-slim movement generators (actuators), we strive to allow the needles to apply repetitive movements to the skin.

PVDC foils, metallized on both sides, or ceramic layers are currently in the process of application and are expected to do this this job. The target is to allow for keeping skin channels open and assist diffusion of APIs.  

This is at least the potential for a tremendous step ahead.

Current state

A patch-like system, driven by neat and slim electronic circuits appears possible. Yet, just the piezoelectic and the microneedle part is miniaturized and applicable to human skin in vitro.

Goals and Applications 

It is our goal to further explore applicability and "marriage" of the three to four different technologies in a simple, single device. No severe obstacles appear to us as preventive (but nothing is without risk). Anyway, the first target is to optimize the frequency, intensity and repetitions before the final device will be ordered and constructed.  

Once combined in such a fashion, we will strive to cooperations with pharmaceutical companies to get single API product applications on their way.

Theoretical candidates are those with too low lipid solubility to overcome the barrier, the practical subgroup of them being the ones with distinct therapeutic advantages for this route of application.The applicability for hydrophilic, highly active APIs like proteins, RNAs but also specific small molecules appears promising.